A Novel and Versatile Entry to Asymmetrically Substituted Pyrazines
نویسندگان
چکیده
منابع مشابه
Enone-alkyne reductive coupling: a versatile entry to substituted pyrroles.
The reductive coupling of enones or enals with alkynes, followed by olefin oxidative cleavage and Paal-Knorr cyclization, provides a versatile entry to a variety of pyrrole frameworks. A number of limitations of alternate entries to the requisite 1,4-dicarbonyl intermediate are avoided. Classes of pyrroles that are accessible by this approach include 2,3-, 2,4-, 1,2,3-, 1,2,4-, 2,3,5-, and 1,2,...
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In the context of a broader program directed toward the synthesis of analogues of the isoquinoline-containing natural product cortistatin A, we wished to prepare a diverse array of highly substituted isoquinoline coupling partners, but routes to the complex heterocyclic structures we envisioned were lengthy or impractical using classical or moremodern methods. Herein we report a method for the ...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2008
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo801755t